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Diabetes Vaccine to be Tested in 2018
Scientists behind a prototype vaccine to prevent children from getting type 1 diabetes are looking to test it on humans next year, it has been announced. For 20 years, a team of researchers from Finland's University of Tampere have been working on a drug which aims to protect the body against a virus which triggers type 1 diabetes. Now, following successful tests on mice, they are planning to start clinical trials in 2018, although no results of significance are expected for eight years. The treatment would not cure type 1 diabetes, but potentially stop it from developing in children who get a certain virus. Researchers from across the world have so far failed to understand why insulin-producing beta cellsare firstly identified and then destroyed, which characterises the development of the condition. However, genetics could hold the key in creating different types of 'ID tags' known as human leukocyte markers, which flag up the beta cells. Professor Heikki Hyöty, from the university's School of Medicine, has developed a theory behind one of the ways this process is started, involving an infection by a type of enterovirus. This group of viruses can also cause polio, hepatitis and meningitisas well as hand, foot and mouth disease. The Finnish team has already established a link between a strand of enterovirus known as coxsackievirus B1 and the reaction that sparks the body into attacking beta cells. In 2014, Professor Hyöty found that six strands of the B group of coxsackieviruses were linked to type 1 diabetes in children. Also, data from American suggests that, in 2007, a quarter of the 444 known enterovirus infections across the country were caused by coxsackievirus B1. Professor Hyöty's 2014 study concluded: "One can estimate from the generated data that less than five per cent of CVB1-infected children go on to develop type 1 diabetes." This represents potentially hundreds of youngsters globally going on to get type 1 diabetes every year because of this virus and the number could be higher if other members of the virus group also damage the beta cells. Professor Hyöty added: "Already now it is known that the vaccine is effective and safe on mice. The developing process has now taken a significant leap forward as the next phase is to study the vaccine in humans. "Additionally, the vaccine would protect from infections caused by enteroviruses such as the common cold, myocarditis, meningitis and ear infections." Source: Jack Woodfield DiabetesUK
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Scientists from Finland are testing a prototype type 1 diabetes vaccine on humans next year. Their aim is to be able to work out how to prevent children from developing the condition.
July 25 2017
Type 1 Diabetes and Children There are 2 types of diabetes, type 1 and type 2. This guide talks about type 1 diabetes and how it is developed. Type 1 diabetes usually happens to young people. You don’t catch diabetes, it isn’t a bug. You ‘develop’ diabetes. When doctors find someone has type 1 diabetes, this is called being diagnosed. People with type 1 diabetes are usually diagnosed when they are under 10. Type 1 diabetes happens when the body does not produce enough insulin. This means that glucose produced in the breakdown of food (digestion) stays in the blood. Following diagnosis with type 1 diabetes, the body requires insulin injections, or insulin using an insulin pump. Insulin injections are usually done after breakfast, and after supper. However, this changes depending on the patient and the insulin used. Some insulin lasts for a short time, and some lasts for a long time. But your doctor will tell you all about that.